In this work, we explore the spatio-temporal regulation of RhoA activity by DLC1. We show that knocking out DLC1 in REF52 fibroblasts leads to increased ...

Summary: The manuscript of Heydasch et al. addresses the spatiotemporal regulation of Rho GTPase signaling in living cells and its coupling to the mechanical ...

The iLID module is anchored to the plasma membrane by a Stargazin anchor that displays slow diffusion, allowing better focussing of optogenetic activation. Upon ...